Granville County Health Department and Vance County Health Department became Granville-Vance District Health Department on April 1, 1974.  At the time of the merger each county health department had approximately 20 employees offering core public services (Child Health, Maternal Health, Family Planning, Communicable Disease, Immunization, Environmental Health, WIC, and Health Education/Promotion), as well as Home Health and an orthopedic clinic.

In 2015, Granville-Vance District Health Department rebranded itself and is now referred to as Granville Vance Public Health.  Today, Granville Vance Public Health employs approximately 70 staff across the two counties and is still providing the core public health services along with several other programs that are important to the community, including Primary Care, Care Management for Children and Pregnant Women, Dental, Minority Diabetes Prevention, CenteringPregnancy(R), and Opioid Use Disorder programs such as Medication Assisted Treatment (MAT) and Naloxone.